RHYTHM AI announces publication of successful STAR Mapping™ clinical outcome trial that…

…identified Atrial Fibrillation (AF) drivers in all study patients

Trial Patients

30 patients with persistent AF were included in the trial.  Three patients had AF terminated during the Pulmonary Vein Isolation (PVI) procedure


Commercially available multipolar catheters and equipment were used to gather sequential data for STAR Mapping in the remaining 27 patients

Result Highlights

AF drivers were identified in 100% of patients using STAR Mapping

A positive response (AF termination or Cycle Lengths slowing of ≥30ms) was achieved with STAR Mapping guided ablation in all 27 patients

81.5% of patients (22 of 27) undergoing STAR guided ablation were free from AF at an average follow up time of 17.3 months without the need for antiarrhythmic drug


STAR-guided AFD ablation through sequential mapping with a multipolar catheter effectively achieved an ablation response in all patients. AF terminated in a majority of patients, with a high freedom from AF/atrial tachycardia off antiarrhythmic drugs at long-term follow-up. isolation.

Honarbakhsh S, Schilling RJ, et al; Circ Arrhythm Electrophysiol, 2020

The full clinical paper can be found by following the link below.

View White Paper

STAR Mapping™ in Proof of Concept Studies Suggest that…

STAR Mapping™ has shown improvement in long term outcomes of persistent AF ablation in patients.

35 persistent AF patients were evaluated:

Followed up for >1 year (mean 18.5 months)

Extended ECG recordings and detailed clinical assessments were performed.

80% of patients were free of any abnormal rhythm

Free from abnormal rhythm with no need for any antiarrhythmic medication.

A large multi-centre study using current mapping technology published in 2015 demonstrated 48% of patients were free from documented atrial fibrillation at 18 months without antiarrhythmic medication.

The remaining 20% of patients

Of the remaining 20% only a single patient had a recurrence of AF.

The remaining 6 had recurrence of a regular rhythm that was unable to disorganise into AF.


This proof of concept study indicates that catheter ablation using a 3D mapping system with STAR Mapping™ may lead to significantly better procedural outcomes than when using 3D mapping in isolation.

35 Patients with Persistent AF 14 Months

Clinical Evidence Chart

Honarbakhsh et al JACC EP 2019

The full clinical paper can be found by following the link below.

View White Paper

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